The Atmospheric Carbon Transport - America conducted five airborne campaigns spanning four seasons and three regions in the central and eastern United States to study the transport of atmospheric carbon. Two research aircraft instrumented to measure greenhouse gas mole fractions, associated trace gases, and meteorological variables collected over 1,100 flight hours of research data, distributed across 121 research flights. The aircraft sampled 31 synoptic sequences, including fair-weather and frontal conditions, at altitudes ranging from the atmospheric transport uncertainty, improve regional and seasonal estimates of CO2 and CH4 fluxes, and evaluate the sensitivity of OCO-2 satellite air column carbon dioxide measurements to the regional variability in tropospheric CO2.